3D-Printed Ti6Al4V Scaffolds with Graded Triply Periodic Minimal Surface Structure for Bone Tissue Engineering

The repair of bone defect needs bionic scaffolds that meet biomechanical and bio-structural requirements. triply periodic minimal surface (TPMS) scaffold, with a radial gradient porosity distribution mimicking natural bone, is potential high-performance biomaterial for orthopedic implants. In this paper, TPMS various porosities, which resembled the graded structure human were prepared by selective laser melting (SLM) Ti6Al4V as building material. microstructure characteristics, mechanical properties cell behaviors systematically analyzed. Metallographic results showed grain size exhibited decreasing from outer layer to inner layer. average all as-built samples ranged 55% 71%, pore sizes 333?m 674?m. compression tests Young’s modulus (2.7-7.4GPa) yield strength (233-520MPa) sufficient satisfy requirements nature bone. Additionally, viability measuring proliferation after 48h, 72h 96h expected biocompatibility. significance work improve understanding effect design parameters on growth scaffolds.